abstract：:Infliximab (Remicade) is an antitumor necrosis factor (TNF) therapy effective in both induction and maintenance of remission in Crohn's disease. Identifying predictors of response or relapse to infliximab is important given the potential toxicities and cost of this therapy. Currently available data suggest that concur...

journal_title：Advanced drug delivery reviews

authors： Su C,Lichtenstein GR

更新日期：2005-01-06 00:00:00

abstract：:Cellular processes depend on the fidelity of intracellular membrane traffic. Lipids, proteins, receptor ligands and solute molecules are trafficked to distinct compartments within the cell through both the biosynthetic and endocytic pathways. An appreciation of these pathways is vital for a complete understanding of i...

journal_title：Advanced drug delivery reviews

authors： Watson P,Jones AT,Stephens DJ

更新日期：2005-01-02 00:00:00

abstract：:The choroid plexuses (CPs) are leaf-like highly vascular structures laying in the ventricles. The main function of choroid plexuses is the production of the cerebrospinal fluid (CSF). Although CPs have a unique distribution of ion transporters/channels, the mechanism of CSF production is similar to the production of f...

journal_title：Advanced drug delivery reviews

authors： Redzic ZB,Segal MB

更新日期：2004-10-14 00:00:00

abstract：:In the preparation of biomimetic materials it is often required that efficient methods of polymerization be used, often methods that can lead to biomimetic polymers with relatively narrow molecular weight distribution. Living radical polymerization techniques have successfully been used to create low polydispersity li...

journal_title：Advanced drug delivery reviews

authors： Peppas NA,Ward JH

更新日期：2004-09-22 00:00:00

abstract：:Ruminants have a specialised digestive system that contains anaerobic bacteria and protozoa capable of digesting the cellulosic materials that are so common in plant materials. In addition, their distinct digestive system can change the metabolism and mode of action of some nutrients, medicines or other bioactive mate...

journal_title：Advanced drug delivery reviews

authors： Vandamme TF,Ellis KJ

更新日期：2004-06-23 00:00:00

abstract：:Lipid-coated microbubbles represent a new class of agents with both diagnostic and therapeutic applications. Microbubbles have low density. Stabilization of microbubbles by lipid coatings creates low-density particles with unusual properties for diagnostic imaging and drug delivery. Perfluorocarbon (PFC) gases entrapp...

journal_title：Advanced drug delivery reviews

authors： Unger EC,Porter T,Culp W,Labell R,Matsunaga T,Zutshi R

更新日期：2004-05-07 00:00:00

abstract：:Most antifolate drugs are efficiently transported by the reduced-folate carrier (RFC). However, several also bind with high affinity to the alpha-isoform of the folate receptor (alpha-FR) and there is evidence to suggest that this transport mechanism may contribute to their activity when the receptor is highly overexp...

journal_title：Advanced drug delivery reviews

authors： Jackman AL,Theti DS,Gibbs DD

更新日期：2004-04-29 00:00:00

abstract：:The application of a multidisciplinary approach to study bacterial pathogenesis, along with the recent sequencing of entire microbial genomes have made possible discoveries that are changing the way scientists view the bacterium-host interaction. Today, research on the molecular basis of the pathogenesis of infectious...

journal_title：Advanced drug delivery reviews

authors： Fasano A,Nataro JP

更新日期：2004-04-19 00:00:00

abstract：:The composition and architecture of the stratum corneum render it a formidable barrier to the topical and transdermal administration of therapeutic agents. The physicochemical constraints severely limit the number of molecules that can be considered as realistic candidates for transdermal delivery. Iontophoresis provi...

journal_title：Advanced drug delivery reviews

authors： Kalia YN,Naik A,Garrison J,Guy RH

更新日期：2004-03-27 00:00:00

abstract：:The extracellular matrix represents a complex alloy of variable members of diverse protein families defining structural integrity and various physiological functions. The most abundant family is the collagens with more than 20 different collagen types identified so far. Collagens are centrally involved in the formatio...

journal_title：Advanced drug delivery reviews

authors： Gelse K,Pöschl E,Aigner T

更新日期：2003-11-28 00:00:00

abstract：:Transferrin receptor has been an important protein for many of the advances made in understanding the intricacies of the intramolecular sorting pathways of endocytosed molecules. The unique internalization and recycling functions of transferrin receptor have also made it an attractive choice for drug targeting and del...

journal_title：Advanced drug delivery reviews

authors： Widera A,Norouziyan F,Shen WC

更新日期：2003-11-14 00:00:00

abstract：:A recombinant C-terminal truncated form of the human soluble tumor necrosis factor receptor type I (sTNF-RI) was produced in E. coli. This soluble receptor contains the first 2.6 of the 4 domains of the intact sTNF-RI molecule. A monoPEGylated form of this molecule was produced using a 30 kD methoxyPEG aldehyde with a...

journal_title：Advanced drug delivery reviews

authors： Edwards CK 3rd,Martin SW,Seely J,Kinstler O,Buckel S,Bendele AM,Ellen Cosenza M,Feige U,Kohno T

更新日期：2003-09-26 00:00:00

abstract：:A pharmaceutical formulation is composed of several formulation factors and process variables. Several responses relating to the effectiveness, usefulness, stability, as well as safety must be optimized simultaneously. Consequently, expertise and experience are required to design acceptable pharmaceutical formulations...

journal_title：Advanced drug delivery reviews

authors： Takayama K,Fujikawa M,Obata Y,Morishita M

更新日期：2003-09-12 00:00:00

abstract：:We have entered a new era in understanding CNS circuitry involved in acute and chronic pain. The ability to objectively measure a pain or analgesic state of the brain using non-invasive methods that define neural activation provides the possibility for top-down approaches to drug discovery. These brain maps represent ...

journal_title：Advanced drug delivery reviews

authors： Borsook D,Becerra L

更新日期：2003-08-28 00:00:00

abstract：:The humble origins of the propellant driven metered dose inhaler, as a response to a child's enquiry, initiated an industry which supplies approximately a half billion inhalers globally for the treatment of asthma. These inhalers fall into three major groups: nebulizers; propellant driven metered dose inhalers and dry...

journal_title：Advanced drug delivery reviews

authors： Dalby R,Suman J

更新日期：2003-07-18 00:00:00

abstract：:In spite of significant exposure to drugs and chemicals through breast milk, there are very few reports of documented adverse effects on the infant. It is perhaps appropriate to consider that the presence of drugs and chemicals in milk may have a positive effect on developmental processes of the young infant. New expe...

journal_title：Advanced drug delivery reviews

authors： Berlin CM Jr

更新日期：2003-04-29 00:00:00

abstract：:A polymer stereocomplex is defined as a stereoselective interaction between two complementing stereoregular polymers, that interlock and form a new composite, demonstrating altered physical properties in comparison to the parent polymers. The main interactions, resulting in the complexation, are suggested to rely on s...

journal_title：Advanced drug delivery reviews

authors： Slager J,Domb AJ

更新日期：2003-04-25 00:00:00

abstract：:Biodegradable nanoparticles formulated from poly (D,L-lactide-co-glycolide) (PLGA) have been extensively investigated for sustained and targeted/localized delivery of different agents including plasmid DNA, proteins and peptides and low molecular weight compounds. Research about the mechanism of intracellular uptake o...

journal_title：Advanced drug delivery reviews

authors： Panyam J,Labhasetwar V

更新日期：2003-02-24 00:00:00

abstract：:Peptide nucleic acid (PNA) is a DNA mimic having a pseudopeptide backbone that makes it extremely stable in biological fluids. PNA binds complementary RNA and DNA with high affinity and specificity. These qualities make PNA a leading agent among "third generation" antisense and antigene agents. Unfortunately, fast pro...

journal_title：Advanced drug delivery reviews

authors： Koppelhus U,Nielsen PE

更新日期：2003-02-10 00:00:00

abstract：:Clinical trials of gene therapy for cystic fibrosis suggest that current levels of gene transfer efficiency are probably too low to result in clinical benefit, largely as a result of the barriers faced by gene transfer vectors within the airways. The respiratory epithelium has evolved a complex series of extracellular...

journal_title：Advanced drug delivery reviews

authors： Ferrari S,Geddes DM,Alton EW

更新日期：2002-12-05 00:00:00

abstract：:Prior to the introduction of troglitazone, it had been more than 30 years since the last significant improvement in antidiabetic therapy. In view of the pressing need for more effective oral agents for the treatment of Type 2 diabetes mellitus, troglitazone was granted priority review by the FDA and was launched in th...

journal_title：Advanced drug delivery reviews

authors： Parker JC

更新日期：2002-11-05 00:00:00

abstract：:Solid lipid nanoparticles (SLN) were developed at the beginning of the 1990 s as an alternative carrier system to emulsions, liposomes and polymeric nanoparticles. The paper reviews advantages-also potential limitations-of SLN for the use in topical cosmetic and pharmaceutical formulations. Features discussed include ...

journal_title：Advanced drug delivery reviews

authors： Müller RH,Radtke M,Wissing SA

更新日期：2002-11-01 00:00:00

abstract：:The coiled-coil is a ubiquitous protein folding and assembly motif made of alpha-helices wrapping around each other forming a supercoil. The sequences of coiled-coils are made of seven-residue repeats, called heptads, and thus are polymer-like. Due to its simplicity and regularity, the coiled-coil is the most extensiv...

journal_title：Advanced drug delivery reviews

authors： Yu YB

更新日期：2002-10-18 00:00:00

abstract：:Poly(ortho esters), POE, are synthetic bioerodible polymers that can be prepared as solid materials, or as viscous, injectable polymers. These materials have evolved through a number of families, and the latest member of this family, POE IV, is particularly well suited to drug delivery since latent acid is integrated ...

journal_title：Advanced drug delivery reviews

authors： Barr J,Woodburn KW,Ng SY,Shen HR,Heller J

更新日期：2002-10-16 00:00:00

abstract：:Lack of approved pharmaceutical agents and/or pharmacokinetic data in the literature for exotic, wildlife, and zoo species is a major issue for veterinarians. These practitioners must take approved agents (veterinary or human) and extrapolate their use to non-approved species with little or no scientific basis to supp...

journal_title：Advanced drug delivery reviews

authors： Hunter RP,Isaza R

更新日期：2002-10-04 00:00:00

abstract：:Gene and antisense/ribozyme therapy possesses tremendous potential for the successful treatment of genetically based diseases, such as cancer. Several cancer gene therapy strategies have already been realized in vitro, as well as in vivo. A few have even reached the stage of clinical trials, most of them phase I, whil...

journal_title：Advanced drug delivery reviews

authors： Merdan T,Kopecek J,Kissel T

更新日期：2002-09-13 00:00:00

abstract：:A site-directed method of joining proteins to poly(ethylene glycol) is presented which allows for the preparation of essentially homogeneous PEG-protein derivatives with a single PEG chain conjugated to the amine terminus of the protein. This selectivity is achieved by conducting the reductive alkylation of proteins w...

journal_title：Advanced drug delivery reviews

authors： Kinstler O,Molineux G,Treuheit M,Ladd D,Gegg C

更新日期：2002-06-17 00:00:00

abstract：:Efflux out of cells by P-glycoprotein (P-gp) represents a serious liability for pharmaceuticals, particularly for anti-cancer drugs. Consequently, identification of compounds as potential substrates is important for understanding their bioavailability. Also, the development of agents which reverse this multi-drug resi...

journal_title：Advanced drug delivery reviews

authors： Stouch TR,Gudmundsson O

更新日期：2002-03-31 00:00:00

abstract：:Hydrogels have been used primarily in the pharmaceutical field as carriers for delivery of various drugs, peptides and proteins. These systems have included stimuli-responsive gels that exhibit reversible swelling behavior and hence can show modulated release in response to external stimuli such as pH, temperature, io...

journal_title：Advanced drug delivery reviews

authors： Byrne ME,Park K,Peppas NA

更新日期：2002-01-17 00:00:00

abstract：:A great deal of interest has surrounded the activities of monoclonal antibodies (mAbs), and mAb-drug, toxin and radionuclide conjugates for the treatment of human cancers. In the last few years, a number of new mAb-based reagents have been clinically approved (Rituxan, Herceptin, and Panorex), and several others are n...

journal_title：Advanced drug delivery reviews

authors： Senter PD,Springer CJ

更新日期：2001-12-31 00:00:00

abstract：:Responsive hydrophobically associating polymers can in many ways be considered to be analogous to proteins in their ability to form compact molecules with a defined secondary structure, and hence, functionality. These molecules are characterized by the presence of alternating charged and hydrophobic groups. The balanc...

journal_title：Advanced drug delivery reviews

authors： Tonge SR,Tighe BJ

更新日期：2001-12-03 00:00:00

abstract：:The objective of this review is to summarize the critical steps in intracellular trafficking and the principal factors involved in transgene expression by a comparison of viral and non-viral gene vectors. Intracellular trafficking of viral and non-viral gene vectors are reviewed kinetically as well as from the mechani...

journal_title：Advanced drug delivery reviews

authors： Kamiya H,Tsuchiya H,Yamazaki J,Harashima H

更新日期：2001-11-19 00:00:00

abstract：:Safe nasal vaccines capable of promoting both mucosal and systemic immunity are needed for effective protection against bacterial and viral pathogens. While parenteral cytokine treatment could lead to unwanted toxicity, the nasal delivery route results in low but biologically active serum cytokine levels. Interleukin ...

journal_title：Advanced drug delivery reviews

authors： Boyaka PN,McGhee JR

更新日期：2001-09-23 00:00:00

abstract：:Intramammary infections (IMIs) represent a major feature in bovine pathology. The treatment of IMIs concern antimicrobial substances. Therapeutic strategies involve administration of immediate release formulations during lactation with or without long-acting formulations during the dry period. Current treatments are n...

journal_title：Advanced drug delivery reviews

authors： Gruet P,Maincent P,Berthelot X,Kaltsatos V

更新日期：2001-09-01 00:00:00

abstract：:With inhalational delivery the alveolar epithelium appears to be the appropriate lung surface to target for the systemic delivery of macromolecules, such as therapeutic proteins. The existence of a high numerical density of smooth-coated or non-coated plasma membrane vesicles or invaginations within the alveolar epith...

journal_title：Advanced drug delivery reviews

authors： Gumbleton M

更新日期：2001-07-28 00:00:00

abstract：:This review attempts to summarize our present state of knowledge of mitochondria in relation to a number of areas of biology, and to indicate where future research might be directed. In the evolution of eukaryotic cells mitochondria have for a long time played a prominent role. Nowadays their integration into many act...

journal_title：Advanced drug delivery reviews

authors： Scheffler IE

更新日期：2001-07-02 00:00:00

abstract：:Numerous drugs are known to deplete mitochondrial DNA (mtDNA) from mammalian cells. These include DNA polymerase gamma and type II topoisomerase inhibitors, lipophilic cationic compounds, and DNA intercalating and non intercalating agents. The effects of these drugs on mtDNA metabolism will be discussed and potential ...

journal_title：Advanced drug delivery reviews

authors： Rowe TC,Weissig V,Lawrence JW

更新日期：2001-07-02 00:00:00

abstract：:The stratum corneum forms the outermost layer of the skin and is essentially a multilamellar lipid milieu punctuated by protein-filled corneocytes that augment membrane integrity and significantly increase membrane tortuosity. The lipophilic character of the stratum corneum, coupled with its intrinsic tortuosity, ensu...

journal_title：Advanced drug delivery reviews

authors： Kalia YN,Guy RH

更新日期：2001-06-11 00:00:00

abstract：:Amphotericin B colloidal dispersion (ABCD) is a near 1:1 discoidal complex of amphotericin B (AMB) and sodium cholesteryl sulfate (SCS) arranged as a bilayer of SCS interspersed with AMB via noncovalent interactions. The complex is stable in blood and plasma with minimal dissociation. In vitro and in vivo studies show...

journal_title：Advanced drug delivery reviews

authors： Guo LS

更新日期：2001-04-25 00:00:00

abstract：:Experimental and computational approaches to estimate solubility and permeability in discovery and development settings are described. In the discovery setting 'the rule of 5' predicts that poor absorption or permeation is more likely when there are more than 5 H-bond donors, 10 H-bond acceptors, the molecular weight ...

journal_title：Advanced drug delivery reviews

authors： Lipinski CA,Lombardo F,Dominy BW,Feeney PJ

更新日期：2001-03-01 00:00:00